MCQ ON GENETICS- PART 2

MCQ ON GENETICS- PART 2

• A nonsense mutation involves:

1. A regulatory sequence.
2. An AG splice acceptor site.
3. The creation of a different amino acid.
4. The creation of a stop codon.

Ans- 4

• In DNA adenine normally pairs with:

1. Cytosine
2. Guanine
3. Thymine
4. Uracil

Ans- 3

• Section of DNA that codes for a protein is called?

1. Gene
2. Allele
3. Plasmid
4. Chromosome

Ans- 1

See also…DIFFERENCE BETWEEN GENE AND ALLELE

• In RNA adenine normally pairs with:

1. Cytosine
2. Guanine
3. Thymine
4. Uracil

Ans- 4

• Exon skipping is associated with:

1. Non-sense mutation
2. Regulatory mutation
3. RNA processing mutation
4. Silent mutation

Ans- 3

• The normal human chromosome diploid number is:

1. 23
2. 24
3. 46
4. 48

Ans- 3

• In meiosis, recombination occurs in:

1. metaphase I
2. prophase I
3. metaphase II
4. prophase II

Ans- 2 (Synapsis and recombination occur in prophase in the first meiotic division.)

See also…MITOSIS & MEIOSIS- CELL DIVISION

• Which of the following is an example of monosomy?

1. 46, XX
2. 47, XXX
3. 69, XYY
4. 45, X

Ans- 4 (Monosomy implies loss of a single chromosome. This is the commonest cause of Turner syndrome)

• The presence of two or more cell lines from different zygotes in a single individual is known as:

1. Mosaicism
2. Diploidy
3. Aneuploidy
4. Chimaerism

Ans- 4

• In a Robertsonian translocation fusion occurs at the:

1. Telomeres
2. Centromeres
3. Histones
4. Ends of the long arms

Ans- 2 (A Robertsonian translocation is a specific type of translocation in which fusion occurs at or very close to the centromeres)

• Which of the following conditions is caused by a trinucleotide (triplet) repeat expansion?

1. Cystic fibrosis
2. Huntingtone disease
3. Osteogenesis imperfect
4. Muscular dystrophy

Ans- 2 (Huntington disease is caused by expansion of a CAG repeat)

• Large triplet repeat expansions can be detected by:

1. Western blotting
2. Southern blotting
3. Polymerase chain reaction
4. None of the above

Ans- 2

• The most common chromosome abnormality in first trimester spontaneous miscarriages is:

1. Trisomy
2. Monosomy
3. Triploidy
4. Tetrasomy

Ans- 1

TYPES OF CHROMOSOME-STRUCTURE&DEFINITION

• Which of the following karyotypes is not compatible with survival to birth?

1. 47, XY, +13
2. 47, XX, +18
3. 47, XY, +21
4. 45, Y

Ans- 4 (The human embryo cannot survive without an X chromosome.)

• The DiGeorge/Shprintzen syndrome is caused by a deletion in which chromosome?

1. 4
2. 7
3. 15
4. 22

Ans- 4

• In which pattern of inheritance male to male transmission is a key feature?

1. Autosomal dominant
2. Autosomal recessive
3. X-linked dominant
4. X-linked recessive

Ans- 1

• Consanguinity shows a strong association with which pattern of inheritance?

1. Autosomal dominant
2. Autosomal recessive
3. X-linked dominant
4. X-linked recessive

Ans- 2

• Which of these is a correct type of mutation?

1. Transcription
2. Polymerase
3. Addition
4. Substitution

Ans- 4

WHAT IS MUTATION- AN OVERVIEW & TYPES

• Which of the following disorders does not show X-linked inheritance?

1. Haemophilia A
2. Haemophilia B
3. Tay-sach disease
4. Duchene muscular dystrophy

Ans- 3 (Tay-Sachs disease shows autosomal recessive inheritance.)

• Which of the following would result in Angelman syndrome?

1. Maternal UPD 15
2. Paternal UPD 15
3. Deletion in the paternally derived chromosome 15
4. A mutation in the SNRPN promoter

Ans- 2

• Leber’s hereditary optic atrophy is caused by a mutation in:

1. Chromosome 18
2. Chromosome 12
3. Chromosome 21
4. Mitochondrial DNA

Ans- 4

• Which of the following statements is true about Mendel?

1. His discoveries concerning genetic inheritance were generally accepted by the scientific community when he published them during the mid-19^th century
2. He believed that genetic traits of parents will usually blend in their children.
3. His ideas about genetics apply equally to plants and animals.
4. None of these.

Ans- 3

Read also… MENDEL’S LAW OF INHERITANCE

• When the genotype consists of a dominant and a recessive allele, the phenotype will be like.

1. The dominant allele
2. The recessive allele
3. Both
4. Neither

Ans- 1

See also…
MCQ ON GENETICS & PLANT BREEDING- PART1
MCQ ON GENETICS- PART 3
DIFFERENCE BETWEEN PHENOTYPE AND GENOTYPE
MCQ ON GENETICS & PLANT BREEDING- PART1
MCQ ON AGRONOMY- PART 1